Our real age may be different from the age that appears to be our brain
Julian Tromoor / Almi
Seven genes have been published by rapid aging of the brain, especially – but 13 drugs and supplements can reduce their effects.
The activity of many genes contributes to the difference between our real age and the biological era of our brain, it is defined that how old our cells are, we indicate that we are known as a brain age interval.
To find genes that accelerate brain aging and widen this difference, Zhengxing Huang At the University of Zhejiang in China and his colleagues trained a deep learning model called 3D-VIT on some medical records and used it to examine others.
He then used it to analyze the data of about 39,000 people, who had information about health, genetic and lifestyle, with biological samples, stored in UK Biobank. These participants were an average of 64 years old, and about half were women.
The 3D-VIT identified the signature in the MRI scan of the participants, which can be used to estimate their biological brain age. Quick aging signs are especially known as lentiform nucleus in brain regions, such as attention and working memory, and the back of internal capsules, and the back of the internal capsules, which connects various areas to the brain’s cerebral cortex – is used for thoughts and language processing.
Huang and his colleagues also found that the score of the participants was scored on the cognizance tests as their brain age increased.
With the size of their approximate brain gaps, 64 influential genes were flagged off compared to their gene variants, but Huang and his colleagues focused on seven: Spoof, Tnfsf12, Gzmb, Sirpb1, Ganali, NMB And C1RLPartly because all of them have a particularly strong effect on the aging of the brain.
Clinical trials have also shown that their activity can be targeted by 13 drugs or supplements. These include collaclaciferol, a supplement for vitamin D deficiency; DasatinibA leukemia drug; Diclofenac, a non-steroidal anti-inflammatory; Doconexent, an omega -3 fatty acids; Estradiol, the type of estrogen is usually used in hormone replacement therapy; Hydrocartisone, usually used to treat eczema; And mecmilamine, a drug that reduces blood pressure.
Others were NicotinePRASTERONE, which relieves vaginal pain during sex during menopause; Supplements Quercetin and Resveratrol; Sirolimus, which is usually used to suppress the immune system after a kidney transplant; And testosterone.
But researchers wrote that people should be encouraged to consider the possible risks associated with drugs or may have unexpected negative consequences of these interventions as supplements to slow down aging “.
Many genes have an effect on brain aging, but here authors have used an approach that prioritizes people with the greatest effect. Dario welenzano Jena at Liboniz Institute when aging in Jena, Germany. “The function provides a solid goal for direct follow -up experimental and clinical intervention.”
But it is difficult to tell how big effect these genes are in fact on aging of brain. Richard Sio King’s College at London. “Just because you have a certain genetic profile, it does not mean that genes will always play a role.”
The genes can be silenced or switched by various lifestyle and environmental factors, such as smoking and high alcohol consumption. These can also motivate people to cognitive decline or brain aging.
Because the study used data in the UK biobank, we do not know what conclusions translate people around the world, Sio says. They say that there is a need for work in other population in Africa, South America and East Asia, to find out that it to find out.
Subject:
(Tagstotransite) Medical Drugs (T) Brain (T)
