Researcher from Florida Atlantic University‘S Schmidt College of Medicine The National I Institute of the National Institute of Health (NIH) has received a grant of five years, $ 1.9 million, which is for a promising and novel method for treating degenerative diseases by replacing damaged laxity cells with new cells. .
New replacement cells can be genetically engineered in the laboratory through the programming of fetal stem cells that can serve as a universal precursor for the formation of mature cells and tissues. Although many strategies have been designed to program immature stem cells in functional adult cells, a major stum is identifying all requirements for adult cell formation.
With this NIH grant, under the leadership of the research team, lead investigator Mark kantoroPhD, Associate Dean of Graduate Programs and Professor of Biomedical Science; And Lisa a. BrainonPhD, Research Professor; The FAU will determine the college of medicine of medicine, the novel mechanism that converts the immature eye lens forever cells into functional transparent cells.
The Katoro Laboratory Team, which includes Josh Destham, PhD, FAU’s Institute for Human Health and Disease Intervention Functioned Post-Doctoral Fellowi-health), It turns out that low oxygen levels (hypoxia) are a major driver of cellular reprograming events that lead to the formation of mature transparent lens cells. This new grant wants to identify routes that control this hypoxia-inspired cellular change event.
“This research, led by the Cantoro Laboratory, is a game-changer for the future of regenerative medicine,” Lewis S NelsonMD, Dean and Head of Health Affairs, Fau Schmidt College of Medicine. “By highlighting accurate requirements to convert stem cells into fully functional adult cells, we are addressing one of the most important challenges in treating degenerative diseases. This success has the ability to dramatically improve the patient’s consequences by offering new hope to restore damaged tissues and organs, ultimately enhances both quality and longevity of life. ,
Regenerative treatment for degenerative diseases rely on understanding how immature cells develop in their mature forms.
“In particular, our work will check the requirement for hypoxic reaction in control of lens gene expression, a role played by hypoxic reaction, hypoxia-inducable transcription factor 1 or HIF1A, and oxygen-inspired epichetic amendments, which regulate DNA enrichment.” , “These novel studies, using lens cells as a model system, provide clues in the development of strategies for more complex cells and engineering of tissues and therefore novel treatment for treatment of degenerative disease.”
In the case of eye lenses, how immature cells are developed in their mature forms, its process involves a layer of epithelial cells on the surface, which infections in fiber cells in the core. To mature to fiber cells and clarify the lens, they have to activate structural proteins such as crystaline, metabolic changes (switching to glycolitis), and the specific gene responsible for removing internal organisms. If this process fails, it can give birth to cataract, a major cause of vision problems.
“While fibroblast growth factors such as molecules are known to start this change while signing this change, we still do not fully understand how to regulate the important genes important for fiber cell maturity,” Brainon said . “The purpose of our latest research is to find out how the condition of hypoxic in the lens core helps gene activation through unique transcriptional and epigenetic mechanisms, fills a significant gap in our knowledge about lens growth.”
The contento laboratory focuses on understanding molecular and mitochondrial mechanisms that run ocular growth and disease. In particular, the lab uses the lanes and retina as a model system to detect cellular discrimination, function and pathological processes. Research has spread to analyze the roles of genes stuck in ocular diseases to study the direct effects of environmental factors such as UV lights and other agents on mitochondrial and cellular functions. Additionally, the laboratory checks how major cellular systems can be manipulated to prevent or treat ordeal of oocular conditions, including age -related cataract formation and macular degeneration, which are the major causes of visual loss worldwide.
An important focus of the Katoro laboratory is highlighting biological programs that guide immature cells during fetalization and to develop and maintain functional tissues throughout their lifetime. The final goal is to use insight to be able to restore the functions of damaged tissues and organs to engineer cell systems and transplanted cells from these studies. To achieve this, researchers have planned many advanced techniques including human genetic analysis, protein biochemistry, molecular and cell biology, confocal and electron microscopy, transgenic and knockout animal models (mouse and smooth), bioinformatics, computational biology and global manifestations. Did. And gene modification analysis.
“Hypoxia activates the major transcription factors and induces chromatin changes, regulating a wide array of cellular processes, including autofaigi and cellular remodeling,” said. “Conclusions from our studies not only illuminate the fundamental biological mechanisms of cellular discrimination, but also provide a basis to develop regenerative remedies and other treatments for age -related and degenerative diseases.”
The Kanto Laboratory has been funded continuously for more than 18 years by the National Eye Institute and NIH and has also received support from the US Health Assistance Foundation and Rand I Institute.
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Charles E. About Schmidy College of Medicine:
Charles E of Florida Atlantic University. Schmidt College of Medicine is one of about 159 recognized medical schools in America. The college was launched in 2010, when Florida Board of Governors took a historic decision, authorizing FAU to grant MD degrees. After receiving approval from the Florida Legislature and the Governor, it became a 134th allopathic medical school in North America. with More than 170 full and part -time faculty and more than 1,300 affiliated faculty, tHe college Each year 80 medical students matriculate and have been recognized nationally for their innovative curriculum. College MS (Thesis and Non-Thysis) and Ph.D. Program in biomedical science with a certificate in genomics and accurate therapy. Taught by top researchers, courses combine the state -of -the -art courses with hand learning, prepares graduates for career in medical, research, industry and academics. To advance the commitment of Florida Atlantic to increase the very essential medical residence positions in Palm Beach County and to ensure that a sufficient and well -trained physician in this area, FAU Charles E. Graduate medical education for the Schmidt College of Medicine Consortium will continue (GME) was in 2011 with five major hospitals in Palm Beach County. The Consortium currently has a five recognition council for graduate medical education (ACGME), including internal medicine, surgery, emergency medical, psychiatry, and neurology, and cardiology, dharamshala and subcutaneous care, geiatrics, vascular surgery, and pulmonary surgery and pullmonary surgery and pullmonary. And there are five fellowships and critical care medicine. The college also manages Florida Atlantic University Medical Group, which offers extensive primary care, and specializes in Marcus Institute of Integrative Health Integrative Pain Management, precise medicine and mental health. The 2023 partnership with Browded Health expands educational medicine, clinical training and research opportunities.
About Florida Atlantic University: The Florida Atlantic University, established in 1961, officially opened its doors as the fifth public university in Florida in 1964. Today, the university serves more than 30,000 undergraduate and graduate students in six complexes located along the South -East Florida coast. In recent years, the university has doubled its research expenses and beaten its peers at student achievement rates. Through the co -existence of access and excellence, Fau is a symbol of an innovative model where the traditional achievement gap disappears. The FAU is named a Hispanic-serving institute, ranked as a top public university by the US News and World Report and is a high research activity institute by Carnegie Foundation for The Advance of Teaching. For more information, go www.fau.edu,
, Damaged organ; Patient results; Stem Sale (T) Florida Atlantic University
