Crohnial intellectual intestinal disease (IBD), including disease and ulcerative colitis, involves chronic inflammation of the gastrointestinal (GI) tract, weakening the mucosal barrier, which leads to increase in permeability. This “dripped intestine” allows harmful substances to penetrate the intestinal lining, deteriorate symptoms, and to pursue the progression of the disease. Existing clinical equipment, such as endoscopy and biopsy, are aggressive and limited, unable to provide real -time insight into mucosal integrity. Non-invasive molecular examination is often very common, remembering localized local areas of inflammation. Therefore, there is an urgent need for new equipment that can continuously monitor the mucosal functions in the GI path, provide timely and specific data.
The University of Maryland team has developed a new solution: GI mucosal designed to monitor integrity in a wireless manner. Published (doi: 10.1038/s41378-025-00877-8) In Microsystems and nanoengeine On February 7, 2025, the study describes the ability to detect changes in mucosal permeability-an early health indicator of health-Via coated with a flexible, four-ties sensor: PSS, a conductive polymer who increases charge transfer. This advancement allows for high sensitivity and stability in the often unexpected environment of the GI tract.
The device uses electrochemical impedance spectroscopy (EIS) to track changes in tissue permeability, send real -time data via Bluetooth. In practical trials, it is successfully distinguished between healthy and damaged tissues, such as excited porcein and mouse from colonic samples. Research demonstrated that a common feature in the device IBD could detect subtle changes in mucous permeability due to tight junction spread. The optimal measurement frequency of 10.5 KHz offered high sensitivity and stability, ensuring that mild cases of inflammation could also be detected. Additionally, the device wirelessly transmitted impedance data, triggering an onboard, which indicates permeability changes-an important feature for the diagnosis of the world.
“This technique represents a major step in the field of GI diagnostics,” the co-writer of the study, Dr. Reza Ghodsi said. “The ability to continuously monitor mucosal barrier integrity in a non-invasive manner can revolutionize the way IBD is diagnosed and managed.”
Given further, this innovative bioemption sensing device has the ability to change the landscape of GI disease management. By providing continuous, non-invasive monitoring of mucosal barrier integrity, it provides more accurate and timely insight than traditional methods. This may be able to facilitate more individual and effective treatments, which may be able to detect initial detection of situations such as IBD. Further research will focus on customizing the device for extensive clinical use and conducting tests to validate its effectiveness in the patient’s population. In the future, it can also increase its applications to other GI disorders, which can improve the patient results.
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Reference
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Original source url
https://doi.org/10.1038/S41378-025-00877-8
Money information
The work was supported by the National Science Foundation ECCS Program, Award #1939236, and NCS Program, Award #1926793.
About this Microsystems and nanoengeine
Microsystems and nanoengeine An online-cavalry is the Open Access International Journal that is dedicated to publishing original research results and reviews all aspects of micro and nano electro mechanical systems for fundamental research. The journal has been published in partnership with the Aerospace Information Research Institute, Chinese Academy of Sciences, which is supported by the laboratory of the state technology.
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